Drug interactions
Lopinavir + Ulipristal
Severity: Major
Lopinavir and Ulipristal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, given with ritonavir, inhibits CYP3A4 and can raise ulipristal exposure. This may increase ulipristal adverse effects and make its antiprogestogenic activity less predictable.
What this interaction means in plain words
Lopinavir and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by ritonavir-boosted lopinavir reduces ulipristal metabolism.
What to do
Avoid the combination where possible and use an alternative contraceptive method such as a copper IUD. If ulipristal is necessary, monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Ulipristal?
MediHelp rates the interaction as major. Lopinavir and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir, given with ritonavir, inhibits CYP3A4 and can raise ulipristal exposure. This may increase ulipristal adverse effects and make its antiprogestogenic activity less predictable.
How serious is the interaction between Lopinavir and Ulipristal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative contraceptive method such as a copper IUD. If ulipristal is necessary, monitor for adverse effects.
What other medicines interact with Lopinavir?
MediHelp also lists interactions of Lopinavir with, for example, Alfuzosin, Avanafil, Cisapride. The full list is on the Lopinavir page.
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