Drug interactions
Lopinavir + Zolpidem
Severity: Moderate
Lopinavir and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, boosted with ritonavir, inhibits CYP3A4 and can increase zolpidem concentrations. This may cause stronger and prolonged sedation and next-day impairment. Ritonavir-containing regimens in particular may amplify the effect.
What this interaction means in plain words
Lopinavir and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Zolpidem belongs to Central Nervous System.
Why it happens
Lopinavir/ritonavir inhibits CYP3A4-mediated zolpidem metabolism.
What to do
Use the lowest zolpidem dose and monitor for oversedation and respiratory depression. Consider a lower dose or an alternative hypnotic if excess sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Zolpidem?
MediHelp rates the interaction as moderate. Lopinavir and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, boosted with ritonavir, inhibits CYP3A4 and can increase zolpidem concentrations. This may cause stronger and prolonged sedation and next-day impairment. Ritonavir-containing regimens in particular may amplify the effect.
How serious is the interaction between Lopinavir and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest zolpidem dose and monitor for oversedation and respiratory depression. Consider a lower dose or an alternative hypnotic if excess sedation develops.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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