Drug interactions
Loprazolam + Mirtazapine
Severity: Moderate
Loprazolam and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can produce additive drowsiness, impaired coordination and slowed reaction time. Benzodiazepines with other CNS depressants can also increase the risk of respiratory depression and falls.
What this interaction means in plain words
Loprazolam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A modulation and mirtazapine's antihistaminic activity.
What to do
Use the lowest effective doses and counsel patients about next-day impairment, driving and alcohol. Take particular care in older patients because of fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Loprazolam with Mirtazapine?
MediHelp rates the interaction as moderate. Loprazolam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can produce additive drowsiness, impaired coordination and slowed reaction time. Benzodiazepines with other CNS depressants can also increase the risk of respiratory depression and falls.
How serious is the interaction between Loprazolam and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients about next-day impairment, driving and alcohol. Take particular care in older patients because of fall risk.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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