Drug interactions
Loprazolam + Modafinil
Severity: Moderate
Loprazolam and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loprazolam is a hypnotic benzodiazepine that opposes modafinil's wakefulness effect. Modafinil is not a reliable antidote for benzodiazepine-related impairment, so patients may be unaware of residual sedation.
What this interaction means in plain words
Loprazolam and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic CNS effects; no established pharmacokinetic interaction.
What to do
Reassess the need for both drugs and counsel patients about residual psychomotor impairment, particularly before driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Loprazolam with Modafinil?
MediHelp rates the interaction as moderate. Loprazolam and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loprazolam is a hypnotic benzodiazepine that opposes modafinil's wakefulness effect. Modafinil is not a reliable antidote for benzodiazepine-related impairment, so patients may be unaware of residual sedation.
How serious is the interaction between Loprazolam and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reassess the need for both drugs and counsel patients about residual psychomotor impairment, particularly before driving.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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