Drug interactions
Loratadine + Midazolam intranasal
Severity: Minor
Loratadine and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal midazolam produces sedation and can cause respiratory depression, which other CNS depressants may intensify. Loratadine is low-sedating, so the added effect is usually small.
What this interaction means in plain words
Loratadine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Monitor sedation and oxygen saturation after midazolam. Avoid additional sedatives where possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Loratadine with Midazolam intranasal?
MediHelp rates the interaction as minor. Loratadine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal midazolam produces sedation and can cause respiratory depression, which other CNS depressants may intensify. Loratadine is low-sedating, so the added effect is usually small.
How serious is the interaction between Loratadine and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation after midazolam. Avoid additional sedatives where possible.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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