Drug interactions
Lorazepam + Lurasidone
Severity: Moderate
Lorazepam and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone is an atypical antipsychotic that can cause somnolence, and with lorazepam it increases sedation and psychomotor impairment. Orthostatic hypotension and falls may also be more likely.
What this interaction means in plain words
Lorazepam and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and antipsychotic receptor blockade; no relevant pharmacokinetic interaction.
What to do
Monitor sedation and orthostatic blood pressure when starting or adjusting either drug. Counsel about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lorazepam with Lurasidone?
MediHelp rates the interaction as moderate. Lorazepam and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone is an atypical antipsychotic that can cause somnolence, and with lorazepam it increases sedation and psychomotor impairment. Orthostatic hypotension and falls may also be more likely.
How serious is the interaction between Lorazepam and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure when starting or adjusting either drug. Counsel about driving and alcohol.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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