Drug interactions
Lorazepam + Papaverine
Severity: Minor
Lorazepam and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine has only modest central depressant effects, and a clinically meaningful added sedation with lorazepam is not well documented. Any effect would likely be mild drowsiness or dizziness.
What this interaction means in plain words
Lorazepam and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorazepam belongs to Central Nervous System; Papaverine belongs to Cardiovascular.
Why it happens
Possible mild additive CNS depression; the mechanism is not well established.
What to do
No routine change is needed; observe for excess drowsiness or dizziness when starting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Lorazepam with Papaverine?
MediHelp rates the interaction as minor. Lorazepam and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine has only modest central depressant effects, and a clinically meaningful added sedation with lorazepam is not well documented. Any effect would likely be mild drowsiness or dizziness.
How serious is the interaction between Lorazepam and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; observe for excess drowsiness or dizziness when starting either drug.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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