Drug interactions
Lorazepam + Phentermine
Severity: Minor
Lorazepam and Phentermine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a stimulant and lorazepam a sedative, and no significant interaction is established. Phentermine may blunt the perceived drowsiness without reducing benzodiazepine impairment.
What this interaction means in plain words
Lorazepam and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorazepam belongs to Central Nervous System; Phentermine belongs to Central Nervous System.
Why it happens
No established mechanism; theoretical opposing CNS effects.
What to do
No routine action is needed. Monitor for anxiety, insomnia or sedation and adjust therapy if the combination is poorly tolerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Lorazepam with Phentermine?
MediHelp rates the interaction as minor. Lorazepam and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phentermine is a stimulant and lorazepam a sedative, and no significant interaction is established. Phentermine may blunt the perceived drowsiness without reducing benzodiazepine impairment.
How serious is the interaction between Lorazepam and Phentermine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor for anxiety, insomnia or sedation and adjust therapy if the combination is poorly tolerated.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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