Drug interactions
Lorazepam + Selinexor
Severity: Moderate
Lorazepam and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological toxicity. Lorazepam may add to these effects and increase the risk of falls and cognitive impairment.
What this interaction means in plain words
Lorazepam and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive CNS adverse effects; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and use the lowest effective lorazepam dose. Take fall precautions and reassess the need for the benzodiazepine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Lorazepam with Selinexor?
MediHelp rates the interaction as moderate. Lorazepam and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological toxicity. Lorazepam may add to these effects and increase the risk of falls and cognitive impairment.
How serious is the interaction between Lorazepam and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and use the lowest effective lorazepam dose. Take fall precautions and reassess the need for the benzodiazepine.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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