Drug interactions
Lorazepam + Temazepam
Severity: Moderate
Lorazepam and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two benzodiazepines together gives duplicated pharmacology and adds to sedation, confusion, ataxia and respiratory depression. The risk of falls and cognitive impairment is particularly high in older adults.
What this interaction means in plain words
Lorazepam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation producing central nervous system depression.
What to do
Avoid routine concurrent use of two benzodiazepines and consolidate to a single agent where possible. If combined briefly, use the lowest doses and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Lorazepam with Temazepam?
MediHelp rates the interaction as moderate. Lorazepam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two benzodiazepines together gives duplicated pharmacology and adds to sedation, confusion, ataxia and respiratory depression. The risk of falls and cognitive impairment is particularly high in older adults.
How serious is the interaction between Lorazepam and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two benzodiazepines and consolidate to a single agent where possible. If combined briefly, use the lowest doses and monitor for oversedation.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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