Drug interactions
Lorazepam + Ziconotide
Severity: Moderate
Lorazepam and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide can cause dizziness, confusion, somnolence and decreased consciousness, and other central nervous system depressants such as lorazepam may intensify these effects. Cognitive impairment may be more severe.
What this interaction means in plain words
Lorazepam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and neuropsychiatric effects.
What to do
Monitor mental status and level of consciousness, and reduce the dose of the concomitant sedative or ziconotide if cognitive impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Lorazepam with Ziconotide?
MediHelp rates the interaction as moderate. Lorazepam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide can cause dizziness, confusion, somnolence and decreased consciousness, and other central nervous system depressants such as lorazepam may intensify these effects. Cognitive impairment may be more severe.
How serious is the interaction between Lorazepam and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status and level of consciousness, and reduce the dose of the concomitant sedative or ziconotide if cognitive impairment develops.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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