Drug interactions
Lorcaserin + Rizatriptan
Severity: Moderate
Lorcaserin and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise serotonergic activity, so combining them could lead to serotonin syndrome with agitation, tremor, hyperthermia and neuromuscular hyperreactivity. Reported cases are rare, but the labeling cautions about serotonergic combinations. Lorcaserin has been withdrawn from the US market.
What this interaction means in plain words
Lorcaserin and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from 5-HT2C agonism by lorcaserin and 5-HT1B/1D agonism by the triptan.
What to do
If used together, monitor for serotonin syndrome particularly after starting or increasing doses. Stop one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Lorcaserin with Rizatriptan?
MediHelp rates the interaction as moderate. Lorcaserin and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs raise serotonergic activity, so combining them could lead to serotonin syndrome with agitation, tremor, hyperthermia and neuromuscular hyperreactivity. Reported cases are rare, but the labeling cautions about serotonergic combinations. Lorcaserin has been withdrawn from the US market.
How serious is the interaction between Lorcaserin and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If used together, monitor for serotonin syndrome particularly after starting or increasing doses. Stop one agent if symptoms occur.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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