Drug interactions
Lorcaserin + Trimipramine
Severity: Moderate
Lorcaserin and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist and was withdrawn from the US market. Combination with a tricyclic antidepressant carries a theoretical risk of serotonin syndrome, and lorcaserin inhibits CYP2D6, which could raise tricyclic levels. The pathway cited in the legacy entry is not well supported.
What this interaction means in plain words
Lorcaserin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects and CYP2D6 inhibition by lorcaserin; the evidence is limited.
What to do
Monitor for serotonin toxicity such as agitation, tremor, diarrhea and hyperthermia, and for tricyclic adverse effects. Consider lowering the trimipramine dose if levels may be raised.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Lorcaserin with Trimipramine?
MediHelp rates the interaction as moderate. Lorcaserin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin is a serotonin 5-HT2C agonist and was withdrawn from the US market. Combination with a tricyclic antidepressant carries a theoretical risk of serotonin syndrome, and lorcaserin inhibits CYP2D6, which could raise tricyclic levels. The pathway cited in the legacy entry is not well supported.
How serious is the interaction between Lorcaserin and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity such as agitation, tremor, diarrhea and hyperthermia, and for tricyclic adverse effects. Consider lowering the trimipramine dose if levels may be raised.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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