Drug interactions
Lorcaserin + Vortioxetine
Severity: Major
Lorcaserin and Vortioxetine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist that also inhibits CYP2D6, so it may raise vortioxetine concentrations. Combining it with a serotonergic antidepressant also carries a theoretical risk of serotonin syndrome.
What this interaction means in plain words
Lorcaserin and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic activity plus CYP2D6 inhibition by lorcaserin, which reduces vortioxetine clearance.
What to do
Avoid the combination where possible; lorcaserin has been withdrawn in many markets. If used, reduce the vortioxetine dose and monitor for serotonin syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Lorcaserin with Vortioxetine?
MediHelp rates the interaction as major. Lorcaserin and Vortioxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorcaserin is a serotonin 5-HT2C agonist that also inhibits CYP2D6, so it may raise vortioxetine concentrations. Combining it with a serotonergic antidepressant also carries a theoretical risk of serotonin syndrome.
How serious is the interaction between Lorcaserin and Vortioxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; lorcaserin has been withdrawn in many markets. If used, reduce the vortioxetine dose and monitor for serotonin syndrome.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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