Drug interactions
Lorlatinib + Losartan
Severity: Minor
Lorlatinib and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and may lower exposure to losartan, which is partly converted to its active metabolite by CYP3A4 and CYP2C9. The clinical effect is likely a modest reduction in blood pressure control.
What this interaction means in plain words
Lorlatinib and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorlatinib belongs to Oncology; Losartan belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by lorlatinib may increase losartan metabolic clearance.
What to do
Monitor blood pressure when lorlatinib is started or stopped and titrate losartan dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Losartan?
MediHelp rates the interaction as minor. Lorlatinib and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib is a moderate CYP3A inducer and may lower exposure to losartan, which is partly converted to its active metabolite by CYP3A4 and CYP2C9. The clinical effect is likely a modest reduction in blood pressure control.
How serious is the interaction between Lorlatinib and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when lorlatinib is started or stopped and titrate losartan dose if control changes.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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