Drug interactions
Lorlatinib + Lovastatin
Severity: Moderate
Lorlatinib and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and may lower lovastatin concentrations, which could reduce its cholesterol-lowering effect. Lorlatinib is also itself associated with hyperlipidemia, so lipid control matters.
What this interaction means in plain words
Lorlatinib and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Lovastatin belongs to Cardiovascular.
Why it happens
Lorlatinib induces CYP3A4, increasing the metabolism of lovastatin and lowering its exposure.
What to do
Monitor lipid levels and increase the lovastatin dose if needed, or switch to a statin that is not CYP3A4-dependent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Lovastatin?
MediHelp rates the interaction as moderate. Lorlatinib and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A inducer and may lower lovastatin concentrations, which could reduce its cholesterol-lowering effect. Lorlatinib is also itself associated with hyperlipidemia, so lipid control matters.
How serious is the interaction between Lorlatinib and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid levels and increase the lovastatin dose if needed, or switch to a statin that is not CYP3A4-dependent.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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