Drug interactions
Lorlatinib + Lurasidone
Severity: Major
Lorlatinib and Lurasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and can reduce lurasidone concentrations, risking reduced antipsychotic effect. The extent is less well characterised than with classic strong inducers.
What this interaction means in plain words
Lorlatinib and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorlatinib belongs to Oncology; Lurasidone belongs to Central Nervous System.
Why it happens
Lorlatinib induces CYP3A4, increasing metabolism of lurasidone, a sensitive CYP3A4 substrate.
What to do
Avoid the combination if possible and choose an antipsychotic less dependent on CYP3A4. If used together, monitor for psychiatric relapse and consider lurasidone dose adjustment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Lurasidone?
MediHelp rates the interaction as major. Lorlatinib and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorlatinib induces CYP3A4 and can reduce lurasidone concentrations, risking reduced antipsychotic effect. The extent is less well characterised than with classic strong inducers.
How serious is the interaction between Lorlatinib and Lurasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose an antipsychotic less dependent on CYP3A4. If used together, monitor for psychiatric relapse and consider lurasidone dose adjustment.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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