Drug interactions
Lorlatinib + Mefloquine
Severity: Moderate
Lorlatinib and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a CYP3A4 inducer and may lower mefloquine concentrations, potentially reducing prophylactic or treatment efficacy. The size of the effect is not well characterized.
What this interaction means in plain words
Lorlatinib and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Mefloquine belongs to Anti Parasitic.
Why it happens
CYP3A4 induction by lorlatinib increases mefloquine clearance.
What to do
Consider an antimalarial that is not CYP3A4-dependent. If mefloquine is used, monitor for treatment failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Mefloquine?
MediHelp rates the interaction as moderate. Lorlatinib and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a CYP3A4 inducer and may lower mefloquine concentrations, potentially reducing prophylactic or treatment efficacy. The size of the effect is not well characterized.
How serious is the interaction between Lorlatinib and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an antimalarial that is not CYP3A4-dependent. If mefloquine is used, monitor for treatment failure.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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