Drug interactions
Lorlatinib + Nisoldipine
Severity: Moderate
Lorlatinib and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may markedly lower nisoldipine concentrations since nisoldipine undergoes extensive CYP3A4 first-pass metabolism. This can cause loss of blood pressure or angina control.
What this interaction means in plain words
Lorlatinib and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Nisoldipine belongs to Cardiovascular.
Why it happens
CYP3A4 induction reduces nisoldipine bioavailability.
What to do
Monitor blood pressure and consider another antihypertensive that is not CYP3A4-dependent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Lorlatinib with Nisoldipine?
MediHelp rates the interaction as moderate. Lorlatinib and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may markedly lower nisoldipine concentrations since nisoldipine undergoes extensive CYP3A4 first-pass metabolism. This can cause loss of blood pressure or angina control.
How serious is the interaction between Lorlatinib and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider another antihypertensive that is not CYP3A4-dependent.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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