Drug interactions
Lorlatinib + Osilodrostat
Severity: Moderate
Lorlatinib and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may lower osilodrostat exposure through CYP3A4 induction, risking loss of cortisol control. Rising cortisol could cause symptoms of hypercortisolism.
What this interaction means in plain words
Lorlatinib and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Osilodrostat belongs to Endocrine.
Why it happens
Lorlatinib induces CYP3A4, increasing osilodrostat metabolism.
What to do
Monitor cortisol levels and clinical signs and adjust the osilodrostat dose as required, reassessing when lorlatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Lorlatinib with Osilodrostat?
MediHelp rates the interaction as moderate. Lorlatinib and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may lower osilodrostat exposure through CYP3A4 induction, risking loss of cortisol control. Rising cortisol could cause symptoms of hypercortisolism.
How serious is the interaction between Lorlatinib and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cortisol levels and clinical signs and adjust the osilodrostat dose as required, reassessing when lorlatinib is stopped.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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