Drug interactions
Lorlatinib + Osimertinib
Severity: Moderate
Lorlatinib and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib is metabolized by CYP3A4, and inducers reduce its exposure. Lorlatinib may weaken its antitumor effect.
What this interaction means in plain words
Lorlatinib and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Osimertinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing osimertinib metabolism.
What to do
Monitor tumor response and consider whether concurrent use is necessary. Follow labeling guidance for CYP3A inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Lorlatinib with Osimertinib?
MediHelp rates the interaction as moderate. Lorlatinib and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib is metabolized by CYP3A4, and inducers reduce its exposure. Lorlatinib may weaken its antitumor effect.
How serious is the interaction between Lorlatinib and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider whether concurrent use is necessary. Follow labeling guidance for CYP3A inducers.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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