Drug interactions
Lorlatinib + Ospemifene
Severity: Moderate
Lorlatinib and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ospemifene is metabolized by CYP3A4 and CYP2C9, and inducers lower its exposure. Lorlatinib may reduce its efficacy for dyspareunia.
What this interaction means in plain words
Lorlatinib and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Ospemifene belongs to Endocrine.
Why it happens
Lorlatinib induces CYP3A4, increasing ospemifene metabolism.
What to do
Monitor symptom relief and consider an alternative therapy if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Lorlatinib with Ospemifene?
MediHelp rates the interaction as moderate. Lorlatinib and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ospemifene is metabolized by CYP3A4 and CYP2C9, and inducers lower its exposure. Lorlatinib may reduce its efficacy for dyspareunia.
How serious is the interaction between Lorlatinib and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom relief and consider an alternative therapy if response is lost.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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