Drug interactions
Lorlatinib + Ribociclib
Severity: Moderate
Lorlatinib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may raise lorlatinib levels through CYP3A4 inhibition, potentially increasing CNS effects, hyperlipidemia and PR interval prolongation. Ribociclib itself also prolongs the QT interval.
What this interaction means in plain words
Lorlatinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lorlatinib, with possible additive cardiac conduction effects.
What to do
Monitor ECG, electrolytes, lipids and CNS symptoms. Reduce the lorlatinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Ribociclib?
MediHelp rates the interaction as moderate. Lorlatinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib may raise lorlatinib levels through CYP3A4 inhibition, potentially increasing CNS effects, hyperlipidemia and PR interval prolongation. Ribociclib itself also prolongs the QT interval.
How serious is the interaction between Lorlatinib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes, lipids and CNS symptoms. Reduce the lorlatinib dose if adverse effects occur.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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