Drug interactions
Lorlatinib + Ripretinib
Severity: Moderate
Lorlatinib and Ripretinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may lower ripretinib concentrations by inducing CYP3A4. Lower exposure could reduce antitumor activity in GIST.
What this interaction means in plain words
Lorlatinib and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Ripretinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing ripretinib metabolism.
What to do
Avoid if possible; if needed, increase ripretinib to 150 mg twice daily per labeling for inducers and monitor response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
Frequently asked questions
Can I take Lorlatinib with Ripretinib?
MediHelp rates the interaction as moderate. Lorlatinib and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may lower ripretinib concentrations by inducing CYP3A4. Lower exposure could reduce antitumor activity in GIST.
How serious is the interaction between Lorlatinib and Ripretinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, increase ripretinib to 150 mg twice daily per labeling for inducers and monitor response and tolerability.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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