Drug interactions
Lorlatinib + Solifenacin
Severity: Moderate
Lorlatinib and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower solifenacin concentrations, potentially reducing its effect on overactive bladder symptoms. The effect is dose-dependent and the clinical consequence is loss of efficacy rather than toxicity.
What this interaction means in plain words
Lorlatinib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Induction of CYP3A4-mediated solifenacin metabolism by lorlatinib.
What to do
Monitor for reduced symptom control and titrate solifenacin to response within the labeled maximum, or switch to an agent not dependent on CYP3A4 if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Solifenacin?
MediHelp rates the interaction as moderate. Lorlatinib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may lower solifenacin concentrations, potentially reducing its effect on overactive bladder symptoms. The effect is dose-dependent and the clinical consequence is loss of efficacy rather than toxicity.
How serious is the interaction between Lorlatinib and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control and titrate solifenacin to response within the labeled maximum, or switch to an agent not dependent on CYP3A4 if control is inadequate.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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