Drug interactions
Lorlatinib + Sonidegib
Severity: Moderate
Lorlatinib and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is mainly cleared by CYP3A4, and lorlatinib may lower its concentrations. Reduced exposure may decrease efficacy in basal cell carcinoma.
What this interaction means in plain words
Lorlatinib and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Sonidegib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing sonidegib metabolism.
What to do
Avoid combination if an alternative exists; otherwise monitor lesion response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Lorlatinib with Sonidegib?
MediHelp rates the interaction as moderate. Lorlatinib and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sonidegib is mainly cleared by CYP3A4, and lorlatinib may lower its concentrations. Reduced exposure may decrease efficacy in basal cell carcinoma.
How serious is the interaction between Lorlatinib and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination if an alternative exists; otherwise monitor lesion response.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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