Drug interactions
Lorlatinib + Tazemetostat
Severity: Moderate
Lorlatinib and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a CYP3A4 substrate and a weak CYP3A inducer, while lorlatinib is a CYP3A4 substrate and a moderate inducer. Each may lower the other's exposure, and the combination could reduce the efficacy of either drug. Lorlatinib may also lower tazemetostat exposure.
What this interaction means in plain words
Lorlatinib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Mutual CYP3A4 induction leads to accelerated metabolism of both drugs.
What to do
Monitor for reduced antitumor response and check lorlatinib tolerability and response. Avoid the combination if an alternative regimen is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Lorlatinib with Tazemetostat?
MediHelp rates the interaction as moderate. Lorlatinib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a CYP3A4 substrate and a weak CYP3A inducer, while lorlatinib is a CYP3A4 substrate and a moderate inducer. Each may lower the other's exposure, and the combination could reduce the efficacy of either drug. Lorlatinib may also lower tazemetostat exposure.
How serious is the interaction between Lorlatinib and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antitumor response and check lorlatinib tolerability and response. Avoid the combination if an alternative regimen is available.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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