Drug interactions
Lorlatinib + Tipranavir
Severity: Major
Lorlatinib and Tipranavir: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir given with ritonavir has net strong CYP3A inhibition and may increase lorlatinib exposure and toxicity, while lorlatinib may lower tipranavir levels. Both effects can be clinically important.
What this interaction means in plain words
Lorlatinib and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorlatinib belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4, reducing lorlatinib clearance; lorlatinib induces CYP3A4, lowering tipranavir exposure.
What to do
Avoid combination; if unavoidable, reduce lorlatinib dose per labeling and monitor lipids, liver enzymes, ECG and HIV viral load.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Lorlatinib with Tipranavir?
MediHelp rates the interaction as major. Lorlatinib and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir given with ritonavir has net strong CYP3A inhibition and may increase lorlatinib exposure and toxicity, while lorlatinib may lower tipranavir levels. Both effects can be clinically important.
How serious is the interaction between Lorlatinib and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; if unavoidable, reduce lorlatinib dose per labeling and monitor lipids, liver enzymes, ECG and HIV viral load.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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