Drug interactions
Lorlatinib + Velpatasvir
Severity: Major
Lorlatinib and Velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and may lower velpatasvir exposure, which could reduce antiviral efficacy and risk virologic failure. A true labeled contraindication is not established, but the interaction is clinically relevant.
What this interaction means in plain words
Lorlatinib and Velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorlatinib belongs to Oncology; Velpatasvir belongs to Anti Virals.
Why it happens
Lorlatinib induces CYP3A4 (and possibly P-gp), increasing velpatasvir clearance.
What to do
Avoid the combination if possible, or delay HCV therapy until lorlatinib is finished. If used together, monitor HCV RNA for response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Carbamazepine + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Bosentan + Velpatasvir Major
- Colchicine + Velpatasvir Major
- Efavirenz + Velpatasvir Major
Frequently asked questions
Can I take Lorlatinib with Velpatasvir?
MediHelp rates the interaction as major. Lorlatinib and Velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorlatinib is a moderate CYP3A inducer and may lower velpatasvir exposure, which could reduce antiviral efficacy and risk virologic failure. A true labeled contraindication is not established, but the interaction is clinically relevant.
How serious is the interaction between Lorlatinib and Velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or delay HCV therapy until lorlatinib is finished. If used together, monitor HCV RNA for response.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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