Drug interactions
Carbamazepine + Velpatasvir
Severity: Contraindicated
Carbamazepine and Velpatasvir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine lowers velpatasvir concentrations and may cause hepatitis C treatment failure.
What this interaction means in plain words
Carbamazepine and Velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Velpatasvir belongs to Anti Virals.
Why it happens
Carbamazepine induces CYP3A4, CYP2B6, and P-gp, decreasing velpatasvir exposure.
What to do
Do not coadminister; switch to a non-inducing anticonvulsant or an alternative HCV regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Bosentan + Velpatasvir Major
- Colchicine + Velpatasvir Major
- Efavirenz + Velpatasvir Major
- Enzalutamide + Velpatasvir Major
Frequently asked questions
Can I take Carbamazepine with Velpatasvir?
MediHelp rates the interaction as contraindicated. Carbamazepine and Velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine lowers velpatasvir concentrations and may cause hepatitis C treatment failure.
How serious is the interaction between Carbamazepine and Velpatasvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; switch to a non-inducing anticonvulsant or an alternative HCV regimen.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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