Drug interactions
Colchicine + Velpatasvir
Severity: Major
Colchicine and Velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits intestinal P-glycoprotein and can raise colchicine exposure. Higher colchicine levels increase the risk of serious toxicity, including neuromuscular effects, bone marrow suppression and gastrointestinal toxicity, especially in renal or hepatic impairment.
What this interaction means in plain words
Colchicine and Velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Velpatasvir belongs to Anti Virals.
Why it happens
Inhibition of P-glycoprotein efflux reduces colchicine intestinal secretion and clearance, increasing systemic exposure.
What to do
Reduce the colchicine dose or frequency according to labeling when coadministration is needed, and monitor for colchicine toxicity. Avoid the combination in patients with renal or hepatic impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Carbamazepine + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Bosentan + Velpatasvir Major
- Efavirenz + Velpatasvir Major
- Enzalutamide + Velpatasvir Major
Frequently asked questions
Can I take Colchicine with Velpatasvir?
MediHelp rates the interaction as major. Colchicine and Velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Velpatasvir inhibits intestinal P-glycoprotein and can raise colchicine exposure. Higher colchicine levels increase the risk of serious toxicity, including neuromuscular effects, bone marrow suppression and gastrointestinal toxicity, especially in renal or hepatic impairment.
How serious is the interaction between Colchicine and Velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the colchicine dose or frequency according to labeling when coadministration is needed, and monitor for colchicine toxicity. Avoid the combination in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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