Drug interactions
Bosentan + Velpatasvir
Severity: Major
Bosentan and Velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower velpatasvir concentrations, risking reduced antiviral efficacy and virologic failure in hepatitis C treatment.
What this interaction means in plain words
Bosentan and Velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Velpatasvir belongs to Anti Virals.
Why it happens
Bosentan induces CYP3A4 and other enzymes, increasing velpatasvir clearance.
What to do
Avoid coadministration as labeling does not recommend moderate inducers. Use an alternative to bosentan or HCV regimen and confirm sustained virologic response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Carbamazepine + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Colchicine + Velpatasvir Major
- Efavirenz + Velpatasvir Major
- Enzalutamide + Velpatasvir Major
Frequently asked questions
Can I take Bosentan with Velpatasvir?
MediHelp rates the interaction as major. Bosentan and Velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan may lower velpatasvir concentrations, risking reduced antiviral efficacy and virologic failure in hepatitis C treatment.
How serious is the interaction between Bosentan and Velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration as labeling does not recommend moderate inducers. Use an alternative to bosentan or HCV regimen and confirm sustained virologic response.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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