Drug interactions
Lormetazepam + Sevoflurane
Severity: Moderate
Lormetazepam and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam is a short-acting hypnotic benzodiazepine, and combined with sevoflurane it increases sedation and can depress breathing. The anesthetic requirement is usually lower.
What this interaction means in plain words
Lormetazepam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Titrate sevoflurane to effect and monitor ventilation and oxygen saturation, including in the recovery period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lormetazepam and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sevoflurane
Frequently asked questions
Can I take Lormetazepam with Sevoflurane?
MediHelp rates the interaction as moderate. Lormetazepam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam is a short-acting hypnotic benzodiazepine, and combined with sevoflurane it increases sedation and can depress breathing. The anesthetic requirement is usually lower.
How serious is the interaction between Lormetazepam and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to effect and monitor ventilation and oxygen saturation, including in the recovery period.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
