Drug interactions
Lornoxicam + Ofloxacin
Severity: Moderate
Lornoxicam and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the CNS stimulatory and seizure-provoking effects of fluoroquinolones. The risk is greater with epilepsy, renal impairment or advanced age.
What this interaction means in plain words
Lornoxicam and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones antagonize GABA-A receptors, and NSAIDs may potentiate this effect, lowering the seizure threshold.
What to do
Avoid the combination in patients with seizure history and use the lowest effective doses. Stop and review if neurological symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Ofloxacin?
MediHelp rates the interaction as moderate. Lornoxicam and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the CNS stimulatory and seizure-provoking effects of fluoroquinolones. The risk is greater with epilepsy, renal impairment or advanced age.
How serious is the interaction between Lornoxicam and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure history and use the lowest effective doses. Stop and review if neurological symptoms appear.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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