Drug interactions
Lornoxicam + Paroxetine
Severity: Moderate
Lornoxicam and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine with lornoxicam increases the risk of upper gastrointestinal bleeding relative to either alone. Elderly patients and those with ulcer history are particularly vulnerable.
What this interaction means in plain words
Lornoxicam and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRI-induced platelet serotonin depletion plus NSAID COX inhibition and mucosal injury produce additive bleeding risk.
What to do
Limit NSAID dose and duration or use paracetamol instead. Add a proton pump inhibitor in at-risk patients and monitor for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Paroxetine?
MediHelp rates the interaction as moderate. Lornoxicam and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine with lornoxicam increases the risk of upper gastrointestinal bleeding relative to either alone. Elderly patients and those with ulcer history are particularly vulnerable.
How serious is the interaction between Lornoxicam and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit NSAID dose and duration or use paracetamol instead. Add a proton pump inhibitor in at-risk patients and monitor for GI bleeding.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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