Drug interactions
Lornoxicam + Tolmetin
Severity: Major
Lornoxicam and Tolmetin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together provides no added therapeutic benefit and increases the risk of gastrointestinal bleeding, ulceration, renal injury and fluid retention.
What this interaction means in plain words
Lornoxicam and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lornoxicam belongs to Musculoskeletal; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive inhibition of COX-1 and COX-2 leads to cumulative gastric mucosal damage, platelet inhibition and renal prostaglandin suppression.
What to do
Avoid concurrent use of two systemic NSAIDs and use a single agent at the lowest effective dose. Consider a different drug class if analgesia is inadequate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Tolmetin?
MediHelp rates the interaction as major. Lornoxicam and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two NSAIDs together provides no added therapeutic benefit and increases the risk of gastrointestinal bleeding, ulceration, renal injury and fluid retention.
How serious is the interaction between Lornoxicam and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two systemic NSAIDs and use a single agent at the lowest effective dose. Consider a different drug class if analgesia is inadequate.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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