Drug interactions
Lornoxicam + Triamterene
Severity: Major
Lornoxicam and Triamterene: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can cause potassium retention and reduce renal function, and triamterene also retains potassium. The combination raises the risk of hyperkalemia and acute kidney injury, and triamterene with NSAIDs has been linked to renal failure.
What this interaction means in plain words
Lornoxicam and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lornoxicam belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
NSAID inhibition of prostaglandin synthesis suppresses renin-aldosterone and renal perfusion, adding to triamterene's blockade of potassium secretion.
What to do
Avoid the combination when possible, using paracetamol as an alternative. If necessary, monitor potassium, creatinine and hydration status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Triamterene?
MediHelp rates the interaction as major. Lornoxicam and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as lornoxicam can cause potassium retention and reduce renal function, and triamterene also retains potassium. The combination raises the risk of hyperkalemia and acute kidney injury, and triamterene with NSAIDs has been linked to renal failure.
How serious is the interaction between Lornoxicam and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible, using paracetamol as an alternative. If necessary, monitor potassium, creatinine and hydration status.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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