Drug interactions
Lornoxicam + Valsartan
Severity: Moderate
Lornoxicam and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can blunt the antihypertensive effect of valsartan and reduce renal function, particularly in volume-depleted, elderly, or renally impaired patients. Hyperkalemia and acute kidney injury may result.
What this interaction means in plain words
Lornoxicam and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Valsartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow, sodium excretion, and potassium excretion, opposing angiotensin receptor blockade.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine, and potassium; use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Valsartan?
MediHelp rates the interaction as moderate. Lornoxicam and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam can blunt the antihypertensive effect of valsartan and reduce renal function, particularly in volume-depleted, elderly, or renally impaired patients. Hyperkalemia and acute kidney injury may result.
How serious is the interaction between Lornoxicam and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine, and potassium; use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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