Drug interactions
Losartan + Mavacamten
Severity: Minor
Losartan and Mavacamten: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized by CYP2C19 and CYP3A4. Raised mavacamten levels can reduce ejection fraction and cause heart failure, and losartan is not an established CYP2C19 inhibitor, so the interaction is mainly theoretical. Both drugs lower blood pressure and may add to hypotension.
What this interaction means in plain words
Losartan and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
Possible weak CYP2C19 inhibition by losartan; additive hypotension is pharmacodynamic.
What to do
Monitor blood pressure and echocardiographic LVEF per mavacamten labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Losartan with Mavacamten?
MediHelp rates the interaction as minor. Losartan and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mavacamten is metabolized by CYP2C19 and CYP3A4. Raised mavacamten levels can reduce ejection fraction and cause heart failure, and losartan is not an established CYP2C19 inhibitor, so the interaction is mainly theoretical. Both drugs lower blood pressure and may add to hypotension.
How serious is the interaction between Losartan and Mavacamten?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and echocardiographic LVEF per mavacamten labeling.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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