Drug interactions
Losartan + Meclofenamic acid
Severity: Moderate
Losartan and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamic acid can weaken the antihypertensive effect of losartan. Together they can also impair renal function and raise potassium, particularly in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Losartan and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes fluid retention and afferent arteriolar constriction, which combined with ARB efferent dilation lowers glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID, and maintain hydration. Prefer an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Meclofenamic acid?
MediHelp rates the interaction as moderate. Losartan and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamic acid can weaken the antihypertensive effect of losartan. Together they can also impair renal function and raise potassium, particularly in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Losartan and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID, and maintain hydration. Prefer an alternative analgesic in high-risk patients.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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