Drug interactions
Losartan + Miconazole
Severity: Minor
Losartan and Miconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan is converted to its active metabolite E-3174 by CYP2C9 and CYP3A4, both of which miconazole can inhibit. Reduced activation could slightly weaken the antihypertensive effect. With vaginal use the clinical impact is probably small.
What this interaction means in plain words
Losartan and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP2C9 and CYP3A4, which may reduce conversion of losartan to E-3174.
What to do
No empirical change is needed. Check blood pressure if miconazole is used for a prolonged period and adjust losartan if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Miconazole
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Miconazole?
MediHelp rates the interaction as minor. Losartan and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Losartan is converted to its active metabolite E-3174 by CYP2C9 and CYP3A4, both of which miconazole can inhibit. Reduced activation could slightly weaken the antihypertensive effect. With vaginal use the clinical impact is probably small.
How serious is the interaction between Losartan and Miconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical change is needed. Check blood pressure if miconazole is used for a prolonged period and adjust losartan if control worsens.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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