Drug interactions
Losartan + Naproxen
Severity: Moderate
Losartan and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can blunt the blood pressure lowering effect of losartan and, together with it, may impair renal function, especially in elderly or volume-depleted patients. Potassium may also rise.
What this interaction means in plain words
Losartan and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins and, combined with angiotensin receptor blockade, lower glomerular filtration pressure and impair potassium excretion.
What to do
Monitor blood pressure, serum creatinine and potassium after starting naproxen and keep the patient well hydrated. Use the shortest NSAID course possible or an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Naproxen?
MediHelp rates the interaction as moderate. Losartan and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can blunt the blood pressure lowering effect of losartan and, together with it, may impair renal function, especially in elderly or volume-depleted patients. Potassium may also rise.
How serious is the interaction between Losartan and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting naproxen and keep the patient well hydrated. Use the shortest NSAID course possible or an alternative analgesic in high-risk patients.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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