Drug interactions
Losartan + Nateglinide
Severity: Minor
Losartan and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide is a CYP2C9 substrate and weak inhibitor in vitro, and could theoretically reduce activation of losartan to E-3174. Clinical relevance has not been shown and no meaningful effect is expected in practice.
What this interaction means in plain words
Losartan and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Nateglinide belongs to Endocrine.
Why it happens
Possible competitive inhibition of CYP2C9 conversion of losartan to its active metabolite.
What to do
No dose change is needed; monitor blood pressure and glucose as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Losartan with Nateglinide?
MediHelp rates the interaction as minor. Losartan and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nateglinide is a CYP2C9 substrate and weak inhibitor in vitro, and could theoretically reduce activation of losartan to E-3174. Clinical relevance has not been shown and no meaningful effect is expected in practice.
How serious is the interaction between Losartan and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood pressure and glucose as usual.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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