Drug interactions
Losartan + Patiromer
Severity: Minor
Losartan and Patiromer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patiromer binds cations in the gut and could in theory bind other oral drugs, but studies with losartan found no clinically important change in exposure. Dose separation is not required for losartan.
What this interaction means in plain words
Losartan and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Patiromer belongs to Miscellaneous.
Why it happens
Theoretical binding of drug in the gastrointestinal tract by the patiromer polymer, not shown to be clinically relevant for losartan.
What to do
No dose separation is required for losartan; continue to monitor serum potassium as usual during patiromer therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Patiromer
- Alogliptin-metformin + Patiromer Moderate
- Canagliflozin-metformin + Patiromer Moderate
- Carvedilol + Patiromer Moderate
- Ciprofloxacin + Patiromer Moderate
- Dapagliflozin-metformin + Patiromer Moderate
- Empagliflozin-metformin + Patiromer Moderate
Frequently asked questions
Can I take Losartan with Patiromer?
MediHelp rates the interaction as minor. Losartan and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Patiromer binds cations in the gut and could in theory bind other oral drugs, but studies with losartan found no clinically important change in exposure. Dose separation is not required for losartan.
How serious is the interaction between Losartan and Patiromer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose separation is required for losartan; continue to monitor serum potassium as usual during patiromer therapy.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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