Drug interactions
Losartan + Rifabutin
Severity: Moderate
Losartan and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP enzymes, including CYP3A4 and CYP2C9, which may lower concentrations of losartan and its active metabolite. This could reduce antihypertensive effect, though rifabutin is a weaker inducer than rifampin.
What this interaction means in plain words
Losartan and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Rifabutin belongs to Anti Bacterial.
Why it happens
Enzyme induction by rifabutin increases metabolic clearance of losartan.
What to do
Monitor blood pressure during and after rifabutin therapy and increase the losartan dose if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Losartan with Rifabutin?
MediHelp rates the interaction as moderate. Losartan and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP enzymes, including CYP3A4 and CYP2C9, which may lower concentrations of losartan and its active metabolite. This could reduce antihypertensive effect, though rifabutin is a weaker inducer than rifampin.
How serious is the interaction between Losartan and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and after rifabutin therapy and increase the losartan dose if control is lost.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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