Drug interactions
Losartan + Sacubitril-valsartan
Severity: Major
Losartan and Sacubitril-valsartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril-valsartan already includes an angiotensin receptor blocker, so adding losartan duplicates RAAS blockade. This raises the risk of hypotension, hyperkalemia and renal impairment without added benefit.
What this interaction means in plain words
Losartan and Sacubitril-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Losartan belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade producing additive effects on blood pressure, renal function and potassium retention.
What to do
Avoid combining; use only one angiotensin receptor blocker. Stop losartan when sacubitril-valsartan is started.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Sacubitril-valsartan?
MediHelp rates the interaction as major. Losartan and Sacubitril-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sacubitril-valsartan already includes an angiotensin receptor blocker, so adding losartan duplicates RAAS blockade. This raises the risk of hypotension, hyperkalemia and renal impairment without added benefit.
How serious is the interaction between Losartan and Sacubitril-valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use only one angiotensin receptor blocker. Stop losartan when sacubitril-valsartan is started.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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