Drug interactions
Losartan + Siponimod
Severity: Minor
Losartan and Siponimod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan is a weak CYP2C9 inhibitor and could modestly raise siponimod exposure. The clinically relevant concern in labeling applies to moderate CYP2C9 inhibitors combined with CYP3A4 inhibitors, which losartan is not.
What this interaction means in plain words
Losartan and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Siponimod belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2C9, a main siponimod metabolic pathway.
What to do
No routine change is needed. Monitor heart rate and for siponimod adverse effects if other CYP2C9 or CYP3A4 inhibitors are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Losartan and Siponimod, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Losartan with Siponimod?
MediHelp rates the interaction as minor. Losartan and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Losartan is a weak CYP2C9 inhibitor and could modestly raise siponimod exposure. The clinically relevant concern in labeling applies to moderate CYP2C9 inhibitors combined with CYP3A4 inhibitors, which losartan is not.
How serious is the interaction between Losartan and Siponimod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor heart rate and for siponimod adverse effects if other CYP2C9 or CYP3A4 inhibitors are also used.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
