Drug interactions
Losartan + Tadalafil
Severity: Moderate
Losartan and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil has vasodilating properties that can add to the blood pressure lowering of losartan. Patients may experience dizziness or symptomatic hypotension, mostly when therapy is started or adjusted.
What this interaction means in plain words
Losartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation through PDE5 inhibition and angiotensin II receptor blockade.
What to do
Monitor blood pressure and symptoms of orthostasis after starting tadalafil. Consider the lowest effective tadalafil dose in patients prone to hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Tadalafil?
MediHelp rates the interaction as moderate. Losartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil has vasodilating properties that can add to the blood pressure lowering of losartan. Patients may experience dizziness or symptomatic hypotension, mostly when therapy is started or adjusted.
How serious is the interaction between Losartan and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of orthostasis after starting tadalafil. Consider the lowest effective tadalafil dose in patients prone to hypotension.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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