Drug interactions
Losartan + Timolol
Severity: Moderate
Losartan and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan can raise serum potassium, and beta-blockers such as timolol can modestly impair potassium shift into cells, so hyperkalemia is possible, particularly in renal impairment or diabetes. Additive blood pressure lowering may also occur.
What this interaction means in plain words
Losartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade reduces aldosterone-mediated potassium excretion while beta-blockade reduces beta-2 mediated cellular potassium uptake, with additive hypotensive effects.
What to do
Monitor serum potassium, renal function and blood pressure after starting or changing doses, especially in patients with CKD or diabetes. Adjust doses if hyperkalemia or symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Timolol?
MediHelp rates the interaction as moderate. Losartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan can raise serum potassium, and beta-blockers such as timolol can modestly impair potassium shift into cells, so hyperkalemia is possible, particularly in renal impairment or diabetes. Additive blood pressure lowering may also occur.
How serious is the interaction between Losartan and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and blood pressure after starting or changing doses, especially in patients with CKD or diabetes. Adjust doses if hyperkalemia or symptomatic hypotension develops.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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