Drug interactions
Losartan + Tolvaptan
Severity: Minor
Losartan and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan is an aquaretic that does not typically raise potassium, so the legacy concern is unfounded. However, volume depletion from tolvaptan may add to hypotension and renal effects with losartan.
What this interaction means in plain words
Losartan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Additive volume depletion and hypotension from aquaresis and angiotensin receptor blockade.
What to do
Monitor blood pressure, fluid status and renal function and serum electrolytes when starting tolvaptan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Losartan with Tolvaptan?
MediHelp rates the interaction as minor. Losartan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan is an aquaretic that does not typically raise potassium, so the legacy concern is unfounded. However, volume depletion from tolvaptan may add to hypotension and renal effects with losartan.
How serious is the interaction between Losartan and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function and serum electrolytes when starting tolvaptan.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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